Depot Medication

 

 

What is antipsychotic medication?

It is a medication that is used for some types of mental distress or disorder, where you may hear voices, have difficulty controlling your thoughts or feel very agitated. This happens most often in manic depression and schizophrenia.

What is depot antipsychotic medication?

It is a special preparation of the medication, which is given by injection. The medication is slowly released into the body over a number of weeks.

What happens when the nurse or doctor gives the depot injection?

  • You go into a private room with the nurse or doctor.
  • The injection is usually given into the buttock.
  • After each injection the medicine stays in your body for a few weeks.

How is it started?

  • The first time you have this treatment you will usually be given a small amount to check that it does not have any bad effects on you.
  • If you have no bad effects from the medication, you start regular injections after a few days.

Why is it usually given into the buttock?

Because the injection is quite thick, it needs to be given into a large muscle, so that there is less (or no) pain and swelling.

Where can you have the injections done?

You can usually decide yourself where to have the injections. The choices might be:

  • At your doctor's surgery 
  • At a community mental health centre
  • At an out-patient clinic
  • At your home.

What's good about having depot injections?

  • You only have to have the medicine once a week or once a month. (Pills have to be taken every day)
  • You are less likely to forget your medicine, so less likely to get ill.
  • The medicine can reduce unpleasant experiences, like hearing voices. It can also help you to feel calmer and think more clearly.

What's bad about having depot injections?

Sometimes this kind of medicine can give you:

  • pain from the injection, which can last for a few days;
  • a feeling of restlessness and anxiety;
  • feeling dizzy when you stand up;
  • weight gain;
  • blurred vision;
  • stiffness in your arms, legs, neck or mouth;
  • after several years of antipsychotic medicine, you may start to have twitches around your mouth (called "tardive dyskinesia");
  • sexual problems - loss of desire in men and women, difficulty in getting an erection or in ejaculating.

You may also have the same side-effects listed above if you are taking oral medication.

Can anything help these side effects?

Yes. Having smaller amounts of the medicine can help, or you can take another medicine to reduce the side effects. It is usually best to reduce the dose of medication to a level where these unpleasant effects do not happen.

What should you do if you get any of these side-effects after a depot injection?

Tell your doctor, nurse or key worker. They will want to help with any problems you have with this medicine.

How often do you have to have these injections?

Between once a week and once a month.

How long do the injections go on?

This will depend on your illness. You should discuss this with your doctor.

Can you say 'no' to having these injections?

Yes you can, just the same as with any other medication. But, if you are kept in hospital under a section of the Mental Health Act, the doctors could make you have treatment (again, like any other medication) even if you don't want it. After 3 months, if you say still don’t want the treatment, the hospital has to ask an independent doctor from a different hospital to see you and decide if you need the medicine or not.

What happens if you miss an injection?

If you miss an injection, you should have another one as soon as you can. If you do not, over a few weeks or months the medicine will stop working and some of the old problems will come back, like hearing voices or feeling troubled or scared. You may start to feel worse than before you started the medicine if you keep missing the depot injections.

What if you are not happy about the injections?

Talk to your doctor, nurse or key worker. They might be able to help you feel OK about it, or suggest a different treatment. If you have any questions about your medicine or if you do not understand anything you have read here please ask your doctor, nurse or key worker. They want to help.

Warnings

Depot injections may make you feel sleepy, so:

  • Be careful with alcohol - it will make you even more sleepy
  • Don't drive a car or work any machinery if you are not fully awake or if you feel the medicine is affecting your concentration
  • Some other medicines, such as sleeping pills or hay fever pills may make you feel more sleepy when you have depot injections.

 

The depot injections currently available in the UK are:

 

Trade name

Proper name

Dose/amount

How often

Modecate  Fluphenazine decanoate  up to 100 milligrams 1 injection every 2 to 5 weeks according to response and severity of condition
Depixol  Flupenthixol decanoate  up to 400 milligrams 1 injection every 2 to 4 weeks according to response and severity of condition
 Haldol Haloperidol decanoate up to 300 milligrams 1 injection every 2 to 4 weeks according to response and severity of condition
Piportil Pipothiazine palmitate up to 200 milligrams 1 injection every 4 weeks
Clopixol Zuclopenthixol Decanoate up to 600 milligrams 1 injection every1 to 4 weeks
Risperdal Consta Risperidone up to 50 milligrams 1 injection every 2 weeks
 
 

 
This leaflet was produced by the Royal College of Psychiatrists' Public Education Editorial Board
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Series Editor: Dr Philip Timms
 
 
Update: January 2010; next due for review: January 2012.
 
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