A Different Life
Career timeline for psychiatry
See the latest jobs
Go to Expert Advice
Approved: May 2014
Published: Nov 2014
Number of pages: 58
Review by: 2019
Download free PDF version
This report is online-only. There are no print copies to
This report reflects the consensus views of a
group of clinicians on the risks and benefits of high-dose
antipsychotic medication for a range of clinical indications for
which antipsychotic medication is commonly used in psychiatric
practice. For each of these indications, the members of the
Consensus Working Group took account of the evidence from the
published literature and their clinical experience, and considered
the clinical implications. While there is little convincing
evidence that off-label prescription of doses of antipsychotic
medication above the licensed dosage range has any therapeutic
advantage in any clinical setting, there is clear evidence for a
greater side-effect burden and the need for appropriate safety
monitoring. The key recommendation is that any prescription of
high-dose antipsychotic medication should be seen as an explicit,
time-limited individual trial with a distinct treatment target.
There should be a clear plan for regular clinical review including
safety monitoring. The high-dose regimen should only be continued
if the trial shows evidence of benefit that is not outweighed by
tolerability or safety problems.
This report replaces an earlier report, CR138 (of the same
title), from year 2006.
Forgotten your password?
Click here to Register