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The Royal College of Psychiatrists Improving the lives of people with mental illness

Psychosis with Coexisting Substance Misuse: The NICE Guideline on Assessment and Management in Adults and Young People

National Collaborating Centre for Mental Health (NCCMH)

Price: £45.00

College members' price: £40.50

Published: Nov 2011

Format: Paperback + free CD-ROM

Number of pages: 326

ISBN: 9781908020307

Psychosis with Coexisting Substance Misuse: The NICE Guideline on Assessment and Management in Adults and Young People

Around 40% of people experiencing psychosis also misuse substances at some point in their lives, which can lead to serious health and social problems for the person and complicate their treatment.

This new guideline covers the assessment and management of adults and young people (aged 14 years and older) who have a clinical diagnosis of psychosis (schizophrenia, bipolar disorder or other affective psychosis) and coexisting substance misuse (harmful use of any psychotropic substance including alcohol and legal or illicit drugs).

Although separate NICE guidelines have been developed for the management of schizophrenia, bipolar disorder and drug and alcohol misuse, the importance of this new guideline on psychosis and substance misuse is in offering advice on how to integrate treatment for people with these commonly coexisting conditions.  

The guideline includes comprehensive reviews of assessment, care pathways and service delivery models, psychological and pharmacological interventions for both conditions, and treatment and services for young people.

Readership: All mental health professionals, especially those working in substance misuse services.

List of the other NICE mental health guidelines

NICE Mental Health Guidelines

These guidelines from NICE set out clear recommendations, based on the best available evidence, for health care professionals on how to work with and implement physical, psychological and service-level interventions for people with various mental health conditions.

The book contains the full guidelines that cannot be obtained in print anywhere else. It brings together all of the evidence that led to the recommendations made, detailed explanations of the methodology behind their preparation, plus an overview of the condition covering detection, diagnosis and assessment, and the full range of treatment and care approaches.

The accompanying free CD-ROM contains all the data used as evidence, including:

  • Included and excluded studies.
  • Profile tables that summarise both the quality of the evidence and the results of the evidence synthesis.
  • All meta-analytical data, presented as forest plots.
  • Detailed information about how to use and interpret forest plots.


  1. Preface
  2. Psychosis with coexisting substance misuse
  3. Method used to develop this guideline
  4. Experience of care
  5. Assessment and care pathways
  6. Service delivery models
  7. Psychological and psychosocial interventions
  8. Pharmacological and physical interventions
  9. Young people with psychosis and coexisting substance misuse
  10. Summary of recommendations
  11. Appendices
  12. References
  13. Abbreviations
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"This is a comprehensive text, with well-referenced and clear areas of discussion related to young people who suffer from psychosis and substance misuse.  In my opinion, professionals who are exposed to and/or treat young persons suffering from psychosis and misuse of substances must be acquainted with this book and not only read it, but have it available in times of need.  This is exactly what I intend to do."

Journal of Clinical Psychiatry