Depot medication

This information is for anyone who would like to know more about depot antipsychotic medication, sometimes known simply as depot medication.


This leaflet provides information, not advice.

The content in this leaflet is provided for general information only. It is not intended to, and does not, mount to advice which you should rely on. It is not in any way an alternative to specific advice.

You must therefore obtain the relevant professional or specialist advice before taking, or refraining from, any action based on the information in this leaflet.

If you have questions about any medical matter, you should consult your doctor or other professional healthcare provider without delay.

If you think you are experiencing any medical condition you should seek immediate medical attention from a doctor or other professional healthcare provider.

Although we make reasonable efforts to compile accurate information in our leaflets and to update the information in our leaflets, we make no representations, warranties or guarantees, whether express or implied, that the content in this leaflet is accurate, complete or up to date.

It is a special preparation of the medication, which is given by injection. The medication is slowly released into the body over a number of weeks.

It is important to know that the medication going into your body by a depot injection is exactly the same as the medication going into your body in tablet form. The only difference is the route through which its enters. This means that the benefits and the side-effects of the depot injection are the same as they would be if you took the drug by mouth.

  • You go into a private room with the nurse or doctor.
  • The injection is usually given into the buttock.
  • After each injection the medicine stays in your body for a few weeks.
  • The first time you have this treatment you will usually be given a small amount to check that it does not have any bad effects on you.
  • If you have no bad effects from the medication, you start regular injections after a few days.
Because the injection is quite thick, it needs to be given into a large muscle, so that there is less (or no) pain and swelling.

You can usually decide yourself where to have the injections. The choices might be:

  • At your doctor's surgery 
  • At a community mental health centre
  • At an out-patient clinic
  • At your home.

How often do you have to have these injections?

Between once a week and once a month.

How long do the injections go on?

This will depend on your illness. You should discuss this with your doctor.

Trade name

Proper name


How often

Modecate Fluphenazine decanoate up to 100 milligrams 1 injection every 2 to 5 weeks according to response and severity of condition
Depixol Flupenthixol decanoate up to 400 milligrams 1 injection every 2 to 4 weeks according to response and severity of condition
Haldol Haloperidol decanoate up to 300 milligrams 1 injection every 2 to 4 weeks according to response and severity of condition
Piportil Pipothiazine palmitate up to 200 milligrams 1 injection every 4 weeks
Clopixol Zuclopenthixol Decanoate up to 600 milligrams 1 injection every1 to 4 weeks
Risperdal Consta Risperidone up to 50 milligrams 1 injection every 2 weeks
Xepilon Paliperidone up to 150 milligrams 1 injection every 4 weeks
ZypAdhera Olanzapine embonate up to 405 milligrams 1 injection every 2 or 4 weeks
Abilify Maintena Aripiprazole up to 400 milligrams 1 injection every month

Which depot to choose should be a joint decision between you and your psychiatrist. All depots are broadly similar in how effective they are. There are some slight differences in some of the effects of the drugs. For example, Clopixol may be more suitable if you are highly agitated, while Depixol may be more suitable if you have a low mood associated with your illness.

There are also differences in the side-effects they may cause, and this will influence your choice of depot.

What's good about having depot injections?

  • You only have to have the medicine once a week or once a month. (Pills have to be taken every day)
  • You are less likely to forget your medicine, so less likely to get ill.
  • The medicine can reduce unpleasant experiences, like hearing voices. It can also help you to feel calmer and think more clearly.

What's bad about having depot injections?

  • Some people feel uncomfortable about having injections, perhaps due to anxiety about needles.
  • Some people experience pain from the injection which can last for a few days - this is usually mild.

Apart from these problems, the side-effects of the medication are the same as with the tablet version of the same drug.

Most depot medications belong to the older group of antipsychotics ('first generation' or 'typical' antipsychotics). These are Modecate, Depixol, Haldol, Piportil and Clopixol. These medications are more likely to cause side-effects such as stiffness or shaking in your arms and legs when compared to the newer medications ('second generation' or 'atypical; antipsychotics) such as Risperidal Consta, Xepilon, ZypAdhere or Abilify Maintena.

Can anything be done to avoid these problems?

Yes. Although having regular injections can be uncomfortable and seem daunting to begin with, it is possible to get used to the process, and you will gradually feel more comfortable with it. Discussing any anxieties with your nurse or doctor can also help.

The physical discomfort of regular injections can also be reduced by alternating the injection site each time. Most depots can be given at different intervals such as weekly, every 2 weeks, every 3 months or monthly. Choosing a dose which allows for less frequent injections can also be helpful.

If you experience side-effects from your depot medication, having smaller amounts of the medicine can help, or you can take another medicine to reduce the side-effects. It is usually best to reduce the dose of medication to a level where these unpleasant effects do not happen.

Yes you can, just the same as with any other medication. But, if you are kept in hospital under a section of the Mental Health Act, the doctors could make you have treatment (again, like any other medication) even if you don't want it. After 3 months, if you say still don’t want the treatment, the hospital has to ask an independent doctor from a different hospital to see you and decide if you need the medicine or not.

If you miss an injection, you should have another one as soon as you can. If you do not, over a few weeks or months the medicine will stop working and some of the old problems will come back, like hearing voices or feeling troubled or scared. You may start to feel worse than before you started the medicine if you keep missing the depot injections.

Talk to your doctor, nurse or key worker. They might be able to help you feel OK about it, or suggest a different treatment. If you have any questions about your medicine or if you do not understand anything you have read here please ask your doctor, nurse or key worker. They want to help.

Depot injections may make you feel sleepy, so:

  • Be careful with alcohol - it will make you even more sleepy
  • Don't drive a car or work any machinery if you are not fully awake or if you feel the medicine is affecting your concentration
  • Some other medicines, such as sleeping pills or hay fever pills may make you feel more sleepy when you have depot injections.

This leaflet was produced by the Royal College of Psychiatrists' Public Education Editorial Board:

  • Series Editor: Dr Philip Timms
  • Expert review: Dr Michael Yousif and Dr Amy Green.

Information about treatments can change rapidly and the College updates its mental health information leaflets regularly.

Published: Apr 2015

Review due: Apr 2018

© Royal College of Psychiatrists