"He's an obsessive football fan."
"She's obsessive about shoes."
"He's a compulsive liar."
We use these phrases to describe people who think about something a lot or do something repeatedly, even when others can't see any reason for it. It isn't usually a problem and, in some lines of work, can even be helpful.
However, some people have distressing thoughts that come into their mind again and again, or experience urges to do the same thing again and again. This can come to dominate your life, stop you from enjoying things and even stop you from doing things you need to do.
- you get awful thoughts coming into your mind, even though you struggle to keep them out
- you have to touch or count things, or repeat the same action like washing over and over again
you could have obsessive-compulsive disorder (OCD).
This leaflet is for anyone who has problems with obsessions or compulsions. We hope it will also be helpful for family and friends – and anyone else who wants to find out about OCD.
It describes what it’s like to have OCD, some of the help that is available, and how well it works, how you can help yourself and how to help someone else who is depressed. It also mentions some of the things we don't know about OCD. At the end of the leaflet, there is a list of other places to find more information, and references to the research on which this leaflet is based.
This leaflet provides information, not advice.
The content in this leaflet is provided for general information only. It is not intended to, and does not, mount to advice which you should rely on. It is not in any way an alternative to specific advice.
You must therefore obtain the relevant professional or specialist advice before taking, or refraining from, any action based on the information in this leaflet.
If you have questions about any medical matter, you should consult your doctor or other professional healthcare provider without delay.
If you think you are experiencing any medical condition you should seek immediate medical attention from a doctor or other professional healthcare provider.
Although we make reasonable efforts to compile accurate information in our leaflets and to update the information in our leaflets, we make no representations, warranties or guarantees, whether express or implied, that the content in this leaflet is accurate, complete or up to date.
The components of OCD
OCD has three main parts.
- Obsessions – the thoughts that make you anxious
- Emotions – the anxiety you feel
- Compulsions – the things you do to reduce your anxiety
Let's look at these in more detail.
Obsessions – the thoughts that make you anxious
"I fear I will harm my baby daughter. I know I don't want to, but bad thoughts keep coming into my head. I can picture myself losing control and stabbing her with a knife. The only way I can get rid of these ideas is to say a prayer, and then have a good thought such as "I know I love her very much". I usually feel a bit better after that, until the next time those awful pictures come into my head. I have hidden away all sharp objects and knives in my house. I think to myself "you must be a horrible mother to think like this. I must be going mad". – Dawn
- Thoughts – single words, short phrases or rhymes that are unpleasant, shocking or blasphemous. You try not to think about them, but they won't go away. You worry that you might be contaminated (by germs, dirt or disease), or that someone might be harmed because you have been careless.
- Pictures in your mind – you see your family dead, or see yourself doing something violent or sexual which is completely out of character - stabbing or abusing someone, or being unfaithful. Such thoughts can be very alarming, for the sufferer, their family and even professionals. But we know that people with obsessions do not act on these thoughts even though they fear they will do so1. A person with OCD is at no greater risk of causing harm than any other member of the public. Even so, if you do have such thoughts, it is best to see a mental health professional with specialist experience in treating OCD.
- Doubts – you wonder for hours whether you might have caused an accident or misfortune to someone. You may worry that you have knocked someone over in your car, or that you have left your doors and windows unlocked.
- Ruminations – you endlessly argue with yourself about whether to do one thing or another so you can't make the simplest decision.
- Perfectionism – you are bothered, in a way that other people are not, if things are not in the exactly the right order, not balanced or not in the right place. For example, if books are not lined up precisely on a bookshelf.
Emotions – the anxiety you feel
"My whole day is spent checking that nothing will go wrong. It takes me an hour to get out of the house in the morning, because I am never sure that I've turned off all the electrical appliances like the cooker, and locked all the windows. Then I check to see that the gas fire is off five times, but if it doesn't feel right I have to do the whole thing again. In the end, I ask my partner to check it all for me again anyway. At work I am always behind as I go through everything several times in case I have made a mistake. If I don't check I feel so worried I can't bear it. It’s ridiculous I know, but I think if something awful did happen, I'd be to blame". – John
- You feel tense, anxious, fearful, guilty, disgusted or depressed.
- You feel better if you carry out your compulsive behaviour, or ritual - but it doesn't last long.
Compulsions – the things you do to reduce your anxiety
"I'm afraid of catching something from other people. I spend hours bleaching all the surfaces in my house to stop the germs, and wash my hands many times each day. I try not to go out of the house if possible. When my husband and children come back home, I ask them in great detail where they have been, in case they have visited somewhere dangerous, like a hospital. I also make them take off all their clothes and wash themselves thoroughly. Part of me realises these fears are stupid. My family are sick of it, but it has gone on for so long now I can't stop". – Liz
- Correcting obsessional thoughts – you think alternative 'neutralising' thoughts like counting, praying or saying a special word over and over again. It feels as though this prevents bad things from happening. It can also be a way of getting rid of any unpleasant thoughts or pictures that are bothering you.
- Rituals – you wash your hands frequently, do things really slowly and carefully, perhaps arrange objects or activities in a particular way. This can take up so much time that it takes ages to go anywhere or do anything useful.
- Checking – your body for contamination, that appliances are switched off, that the house is locked or that your journey route is safe.
- Avoidance – of anything that is a reminder of worrying thoughts. You avoid touching particular objects, going to certain places, taking risks or accepting responsibility. For example, you may avoid the kitchen because you know you will find sharp knives there.
- Hoarding – of useless and worn out possessions. You just can't throw anything away.
- Reassurance – you repeatedly ask others to tell you that everything is alright.
About 1 in every 50 people suffer from OCD at some point in their lives2, men and women equally3. That adds up to over 1 million people in the U.K.
Famous sufferers may include the biologist Charles Darwin, the pioneering nurse Florence Nightingale, the actress Cameron Diaz, and the soccer player David Beckham.
No. The words 'compulsive' and 'obsessive' are sometimes used to describe people who gamble, drink alcohol, shop, use street drugs – or even exercise too much.
However, these behaviours can be pleasurable. The compulsions in OCD never give pleasure – they are always felt as an unpleasant demand or burden.
It varies a lot, but work, relationships and family life are all more productive and satisfying if you are not constantly having to cope with OCD.
Severe OCD can make it impossible to work regularly, to take part in family life – or even to get on with your family.
In particular, your family may become upset if you try to involve them in your rituals.
No – people with OCD do not lose control, even though they often worry a lot about this. They may even ask if they are 'going mad' or 'going crazy'. They will often feel ashamed of how they are and try to hide it, even though it is not their fault.
Although you may worry that you will lose control, we know that this is extremely rare1.
There are several other conditions that may overlap with OCD, or have other similarities.
- Body dysmorphic disorder, or 'the distress of imagined ugliness'. You become convinced that part of your face or body is the wrong shape, and spend hours in front of a mirror checking and trying to cover it up. You may even stop going out in public.
- Trichotillomania – an urge to pull out your hair or eyebrows.
- Health anxiety (hypochondriasis) – a fear of suffering from a serious physical illness, such as cancer.
- People with Tourette's syndrome (where a person may shout out suddenly or jerk uncontrollably) often have OCD as well4 5.
- Children and adults with some forms of autism, like Asperger's syndrome, can appear to have OCD because they like things to be the same, and may like to do the same thing over and over again.
Many children have mild compulsions. They may organise their toys very precisely, or avoid stepping on cracks in the pavement. This usually goes away as they grow older.
Adult OCD usually begins in the teens or early twenties. Symptoms can come and go with time, but sufferers often don't seek help until they have had OCD for many years.
OCD symptoms may improve or go away for a time, but they do often return. Some people will slowly get worse, while for others the symptoms get worse when they are stressed or depressed6 7 8.
Treatment will usually help.
There are many factors that affect whether OCD develops.
- Genes – OCD is a complex disorder. Studies have shown that there are different genetic risk factors involved in whether someone develops OCD. People who have a relative with OCD are more likely to develop OCD than people who don’t.
- Stress – Stressful life events bring it on in about one or two out of every three cases.
- Life changes – Times where someone suddenly has to take on more responsibility – for example, puberty, the birth of a child or a new job9.
- Brain changes – We don't know if it’s a cause, or the result of OCD - but if you have the symptoms for more than a short time, researchers think that there may be changes in how chemical called serotonin (also known as 5HT) works in the brain10.
- Personality – If you are a neat, meticulous, methodical person with high standards you may be more likely to develop OCD. These qualities are normally helpful, but can slip into OCD if they become too extreme.
- Ways of thinking – Nearly all of us have odd or distressing thoughts or pictures in our minds at times – "what if I stepped out in front of that car?" or "I might harm my child". Most of us quickly dismiss these ideas and get on with our lives. But, if you have particularly high standards of morality and responsibility, you may feel that it's terrible to even have these thoughts. So, you are more likely to watch out for them coming back – which makes it more likely that they will.
Here are some things you can do yourself that have helped other people with OCD.
- Remember – it's not your fault and you are not going 'mad'.
- Expose yourself to your troubling thoughts. This sounds odd, but it's a way of getting more control of them. You can record them and listen back to them, or write them down and re-read them. You should do this regularly for around half an hour every day until your anxiety reduces.
- Resist the compulsive behaviour, but not the obsessional thought.
- Don't use alcohol or street drugs to control your anxiety.
- If your thoughts involve worries about your faith or religion, then it can sometimes be helpful to speak to a religious leader to help you work out if this is an OCD problem.
- Contact one of the support groups or websites listed at the end of this leaflet.
- Try a self-help book, such as one of those listed at the end of this leaflet.
Less helpful behaviours
Surprisingly, some of the ways in which you help yourself can actually keep it going:
- Trying to push unpleasant thoughts out of your mind – this usually only makes the thoughts return. For example, try not to think of a pink elephant for the next minute – you will probably find it difficult to think of anything else.
- Thinking 'safe' or 'correcting' thoughts. For example, you spend time putting right a disturbing thought with another thought (like counting to ten) or picture (such as seeing a person alive and well).
- Rituals, checking, avoiding and seeking reassurance will all make you less anxious for a short time – especially if you feel that this might prevent something dreadful from happening. But, every time you do them, you strengthen your belief that they stop bad things from happening. And so you feel more pressure to do them... and so on.
There are various therapies and other types of help available to those with OCD.
Cognitive Behavioural Therapy (CBT)
This is a treatment that helps you change the way you think and behave so you can feel better and get on with your life.
There are two types of CBT used to treat OCD – Exposure and Response Prevention (ERP) and Cognitive Therapy (CT).
Exposure and response prevention (ERP)
This is a way to stop compulsive behaviours and anxieties from strengthening each other. We know that if you stay in a stressful situation long enough, you gradually become used to it and your anxiety goes away11. So, you gradually face the situation you fear (exposure) but stop yourself from doing your usual compulsive rituals, checking or cleaning (response prevention), and wait for your anxiety to go away.
It's usually better to do it in small steps:
- make a list of all the things you fear or avoid at the moment;
- put the situations or thoughts you fear the least at the bottom, the worst ones at the top;
- then start at the bottom and work up, tackling one at a time. Don't move onto the next stage until you have overcome the last one.
This will work best if you practice it often, several times every day, for at least one or two weeks. Each time, you do it for long enough for your anxiety to fall to less than half what it is at its worst – this may take between 10 and 90 minutes to start with. It can help to write down a measure of how anxious you are every 5 minutes, for example, from 0 (no fear) to 10 (extreme fear). You will see how your anxiety rises, then falls.
You may practice some of the steps with your therapist, but most of the time you will be doing it on your own, at a pace you feel comfortable with. It is important to remember that you do not need to get rid of all your anxiety, just enough to manage it better. Remember that your anxiety:
- is unpleasant but won't do you any harm.
- will go away eventually.
- will be easier to face with regular practice.
There are two main ways of trying ERP:
- Guided self-help – You follow the guidance in a book or DVD or use a software programme on a computer, tablet or smart phone app. You also have occasional contact with a professional for advice and support. This approach may be suitable if your OCD is mild, and you have the confidence to try out ways of helping yourself.
- Direct regular contact with a professional, on your own or in a group – This can be face-to-face, over the phone or by video link. This usually happens every week or two weeks at first, and can last for between 45 and 60 minutes at a time. Up to ten hours of contact is recommended to start with, but you may need more.
Here's an example:
John could not leave the house on time for work every day, because he had to check so many things in the house. He worried that the house might burn down, or he might be burgled if he did not check certain things five times each. He made a list of what he was checking, starting with the easiest to tackle. It looked like this:
- The cooker (least feared)
- The kettle
- The gas fire
- The windows
- The doors (most feared)
His first step was to deal with the cooker, as this was his least-feared issue. Instead of making sure that the cooker was switched off several times, he checked it only once (exposure). At first, he felt very anxious. He stopped himself from going back to check again. He agreed not to ask his wife to check everything for him as well, and not to ask her for reassurance that the house was safe (response prevention). His gradually felt less fearful over the next two weeks.
He then moved on to step two (the kettle) and so on. Eventually, he was able to leave the house without any of his checking rituals. He could now get to work on time.
About 3 out of 4 people who complete ERP are helped a lot17. Of those who get better, about 1 in 5 will develop symptoms in the future, and will need extra treatment18. However about 1 in 4 people refuse to try ERP, or else do not finish it19. They may be too fearful, or feel too overwhelmed to do it.
Cognitive therapy (CT)
Cognitive therapy is a psychological treatment which helps you to change your reaction to the thoughts, instead of trying to get rid of them. This can be helpful if you have worrying obsessional thoughts, but do not perform any rituals or actions to make yourself feel better. It can also be added to exposure treatment (ERP) to help overcome OCD.
Cognitive therapy helps you to:
Stop fighting the thoughts
We all have odd thoughts at times, but that is all they are. They do not mean you are a bad person or that bad things are going to happen – and trying to get rid of such thoughts just doesn't work. Cognitive therapy can help you to feel better, even relaxed, while you are having such thoughts. You can learn to treat them with mild curiosity or amusement. If even more unpleasant thoughts happen, you learn not to resist them, to just let them happen, and to think about them in the same way. Such thoughts will often fade away when you stop trying to make them go away.
Change your reaction to your thoughts
You learn to notice when you are having upsetting 'thoughts about thoughts' such as 'I'm a bad person for thinking like this.' You can keep a diary of these unhelpful ways of thinking, then challenge them by asking yourself:
- What is the evidence for - and against - this idea being true?
- How useful is this thought? What's another way to look at this?
- What's the worst/best/most realistic outcome?
- How would I advise a friend who had my problems? If my advice to them is different from the advice I give myself, why?
Deal with responsibility and blame
You tackle unrealistic and self-critical thoughts These can include:
- placing too much importance on your thoughts (they are 'just' thoughts);
- overestimating the chances of something bad happening;
- taking responsibility for bad things happening, even when they are out of your control;
- trying to get rid of all risk in the lives of your loved ones.
Test out unhelpful beliefs
A common fear in OCD is that 'thinking it will make it happen'. Try looking out of the window at a building and think about it falling down. Get a really strong picture in your mind. What happens? Another upsetting belief is that 'having thoughts is as bad as carrying them out'. Imagine your neighbour is unwell and needs some shopping done. Just think about doing it. Does that make you a good person? Not really. In order to be helpful, you have to do the action. The same is true for 'bad' thoughts. It is important to remind yourself that a person with OCD does not carry out their obsessional thoughts.
A cognitive therapist will help you to decide which of your ideas you want to change, and will help you to build new ideas that are more realistic, balanced, and helpful.
Most meetings with a therapist take place at your local GP practice, a clinic or sometimes a hospital. You might be able to have CT over the phone, or in your own home if you can't leave your house.
SSRI (Selective Serotonin Reuptake Inhibitors) antidepressants can help to reduce obsessions and compulsions, even if you are not depressed. Examples include sertraline, fluoxetine, paroxetine, escitalopram and fluvoxamine.
They are generally safe, but may cause side-effects in the first few days like restlessness, a headache, dry mouth or feeling sick12. SSRIs can be used alone, or with CBT, for moderate to severe OCD. Higher doses often work better for OCD13.
If treatment with an SSRI has not helped at all after 3 months, the next step is to change to a different SSRI or a medication called clomipramine. It is best to continue medication for at least 12 months, if it is helping. These medications are not addictive14, but should be cut down slowly over several weeks before stopping.
About 6 out of 10 people improve with medication18. On average, their symptoms reduce by about one third. Anti-obsessional medication does help to prevent OCD coming back for as long as it is taken, even after several years19. But - about 1 in 3 of those who stop medication will get symptoms again in the months after stopping it. This is much less likely to happen if the medication is combined with CBT20.
Exposure therapy (ERP) can be tried without professional help (in milder cases) and is effective and has no side-effects, apart from anxiety. On the other hand, it needs a lot of motivation and hard work, and it does involve some extra anxiety for a short time.
CBT and medication are probably equally effective21 22. If you have only mild OCD, CBT on its own may be effective.
If you have moderately severe OCD, then you could choose either CBT (up to 10 hours of contact with a therapist) or medication (for 12 weeks) first. If you are no better, then you should try both treatments. There may be a waiting list to see a professional of several months in some parts of the country.
If your OCD is severe, it's probably best to try medication and CBT together from the start. Medication alone is an option if your OCD is more than mild, and you don't feel you can face the anxiety of ERP and your OCD. It helps about 6 out of 10 people, but there is more chance that the OCD will return in the future – about 1 in 3 compared with about 1 in 5 for exposure treatments (ERP). It does have to be taken for about a year, and it would not normally be your first choice if you are pregnant or breastfeeding.
It's worth talking these options over with your doctor who should be able to give you any further information you need. You may also want to ask trusted friends or family members.
Your doctor can refer you to a specialist team, which may include psychiatrists, psychologists, nurses, social workers and occupational therapists. They may suggest:
- adding cognitive therapy to exposure treatment or medication;
- taking two anti-obsessional medicines at the same time, such as clomipramine plus citalopram;
- adding antipsychotic medication, such as aripiprazole or risperidone;
- treating other conditions (about 1 in 3 people with OCD also have anxiety, depression, or a problem with alcohol or substance misuse23 24);
- working with your family and carers, to support and advise them.
If you have difficulty living on your own, they may also suggest finding suitable accommodation with people who can help you become more independent.
With treatment, the outlook for most people with OCD is good. However, if you have very severe OCD that has not improved:
- A more intensive daily programme of psychological treatment (CBT and EPR), where you stay in hospital during the treatment.
- A new approach being researched at the moment is deep brain stimulation, using electrical pulses to relieve symptoms.
- A treatment that is rarely offered, if nothing else has helped, is a brain operation called 'ablative neurosurgery'. This is really a last resort as there can be serious side-effects.
Most people get better by attending a GP surgery, or a clinic that can be attached to a hospital. Admission to a mental health unit will only be suggested if:
- your symptoms are very severe, you cannot look after yourself properly or you have thoughts about suicide;
- you have other serious mental health problems, such as an eating disorder, schizophrenia, psychosis or a severe depression;
- your OCD prevents you getting to a clinic for treatment.
Some of these approaches may work in other conditions – but there is not strong evidence for them in OCD:
- Complementary or alternative therapies such as hypnosis, homeopathy, acupuncture and herbal remedies – even though they sound attractive25 26.
- Other types of antidepressant medication, unless you are suffering from depression as well as OCD27.
- Sleeping tablets and tranquillisers (zopiclone, diazepam, and other benzodiazepines) for more than two weeks. These drugs can be addictive28 29.
- Couple or marital therapy – unless there are other problems in the relationship besides the OCD. It is helpful for a partner and family to try and find out more about OCD and how to help.
- Counselling and psychoanalytical psychotherapy30. The more specific treatments described above seem to work much better for the symptoms of OCD. But some people with OCD do find it helpful to talk about their childhood and past experiences.
Your GP may refer you to a local service called 'Improving Access to Psychological Therapies' (IAPT) or to a specialist mental health team.
At the moment, there is a shortage of NHS professionals trained in CBT. In some areas, you may have to wait several months to start treatment. Qualified therapists are often registered with the British Association of Behavioural and Cognitive Psychotherapies.
If the measures outlined in the 'How can I help myself?' section don't help, you can ask your GP about starting SSRI medication in the meantime.
Here are some ways family and friends can offer help and support.
- The behaviour of someone with OCD can be quite frustrating – try to remember that he or she is not trying to be difficult or to behave strangely – they are coping the best they can.
- It may take a while for someone to accept that they need help. Encourage them to read about OCD and talk it over with a professional.
- Find out more about OCD.
- You may be able to help exposure treatments by reacting differently to your relative's compulsions:
- encourage them to tackle fearful situations;
- say 'no' to taking part in rituals or checking;
- don't reassure them that things are alright.
- Don't worry that someone with an obsessional fear of being violent will actually do it. This does not happen.
- It’s best not to try to physically prevent someone from carrying out a ritual.
- Ask if you can go with them to see their GP, psychiatrist or other professional.
A charity for people with OCD, body dysmorphic disorder, compulsive skin picking and trichotillomania.
Help and information line: 0845 390 6232
National support group for children and adults with OCD.
Advice line: 0845 120 3778
An organisation for people with anxiety problems including panic, phobias, OCD and related conditions. Provides support to sufferers, their family and carers. Live chat, email, self-help books, CDs, DVDs and resources.
Helpline: 0844 775774
Information from the National Health Service on conditions, treatments, local services and healthy living.
The main body for the different groups of professionals who offer CBT inside and outside of the NHS. It maintains standards of good practice, provides information, leaflets and keeps a register of members who can be contacted for non-NHS treatment. Tel: 0161 054 304; email: email@example.com
For information on self-help computer packages for anxiety, depression, phobias, panic and OCD see our leaflet on CBT or the following links:
This scheme helps you manage your well-being using self-help reading. The book list is endorsed by people living with the conditions covered and by health professionals, including the Royal College of Psychiatrists. It is widely supported by public libraries.
Information for people with OCD or body dysmorphic disorder, their families and carers, and the public.
Break Free from OCD: Overcoming Obsessive Compulsive Disorder with CBT by Fiona Challacombe, Victoria Bream Oldfield and Paul Salkovskis, Vermillion.
Understanding Obsessions & Compulsions: A self-help manual by Frank Tallis, Sheldon Press.
Overcoming Obsessive-Compulsive Disorder: a self-help book using cognitive-behavioural techniques by David Veale and Robert Willson, Constable and Robinson.
- Veale D, Freeston M, Krebs G, Heyman I, Salkovskis P. Risk assessment and management in obsessive-compulsive disorder. Adv Psychiatr Treat 2009; 15: 332-343.
- National Institute for Health and Care Excellence. Obsessive-compulsive disorder and body dysmorphic disorder: treatment. Clinical guideline 31. NICE; 2005.
- Veale D, Roberts A. Obsessive-compulsive disorder. BMJ 2014; 348: g2183.
- Pitman RK, Green RC, Jenike MA, Mesulam MM. Clinical comparison of Tourette’s disorder and obsessive-compulsive disorder. Am J Psychiatry 1987; 144: 1166-71.
- Kumar A, Trescher W, Byler D. Tourette syndrome and comorbid neuropsychiatric conditions. Curr Dev Disord Rep 2016; 3: 217-21.
- Cougle JR, Timpano KR, Fitch KE, Hawkins KA. Distress tolerance and obsessions: an integrative analysis. Depress Anxiety 2011; 28; 906-14.
- Morgado P, Freitas D, Bessa JM, Sousa N, Cergueira JJ. Perceived stress in obsessive-compulsive disorder is related with obsessive but not compulsive symptoms. Front Psychiatry 2013; 4: 21.
- Overbeek T, Schruers K, Vermetten E, Griez E. Comorbidity of obsessive-compulsive disorder and depression: prevalence, symptom severity, and treatment effect. J Clin Psychiatry 2002; 63: 1106-12.
- McKeon J, Roa B, Mann A. Life events and personality traits in obsessive-compulsive neurosis. Br J Psychiatry 1984; 144: 185-9.
- Murphy DL, Li Q, Engel S, Wichems C, Andrews A, Lesch K-P et al. Genetic perspectives on the serotonin transporter. Brain Res Bull 2001; 15: 487-94.
- Abramowitz JS, Deacon BJ, Whiteside SPH. Exposure Therapy for Anxiety: Principles and Practice. Guildford Press, 2011.
- Devane CL. Comparative safety and tolerability of selective serotonin reuptake inhibitors. Hum Psychopharmacol 1995; 10: S185-S193.
- Bloch MH, McGuire J, Landeros-Weisenberger A, Leckman JF, Pittenger C. Meta-analysis of the dose-response relationship of SSRI in obsessive-compulsive disorder. Mol Psychiatry 2010; 15: 850-5.
- Haddad P. Do antidepressants have any potential to cause addiction? J Psychopharmacol 1999; 13: 300-7.
- Veale D. Cognitive behavioural-therapy for obsessive-compulsive disorder. Adv Psychiatr Treat 2007; 13: 438-46.
- Fesuner JD, Moody T, Lai TM, Sheen C, Khalsa S, Brown J et al. Brain connectivity and prediction of relapse after cognitive-behavioural therapy in obsessive-compulsive disorder. Front Psychiatry 2015; 6: 74.
- Lack CW. Obsessive-compulsive disorder: evidence-based treatments and future directions for research. World J Psychiatry 2012; 22: 86-90.
- Zohar J, Judge R. Paroxetine versus clomipramine in the treatment of obsessive-compulsive disorder. OCD Paroxetine Study Investigators. Br J Psychiatry 1996; 169: 468-74.
- Katz RJ, De Veaugh-Geiss J, Landau P. Clomipramine in obsessive-compulsive disorder. Biol Psychiatry 1990; 28: 401-4.
- Simpson HB, Liebowitz MR, Foa EB, Kozak MJ, Schmidt AB, Rowan V et al. Post-treatment effects of exposure therapy and clomipramine in obsessive-compulsive disorder. Depress Anxiety 2004; 19: 225-33.
- Christensen H, Hadzi-Pavlovic D, Andrews G, Mattick R. Behavior therapy and tricyclic medication in the treatment of obsessive-compulsive disorder: a quantitative review. J Consult Clin Psychol 1987; 55: 701-11.
- Belotto-Silva C, Diniz JB, Malavazzi DM, Valério C, Fossaluza V, Borcato S et al. Group cognitive-behavioral therapy versus selective serotonin reuptake inhibitors for obsessive-compulsive disorder: a practical clinical trial. J Anxiety Disord 2012; 26: 25-31.
- Pallanti S, Grassi G, Sarrecchia ED, Cantisani A, Pellegrini M. Obsessive-compulsive disorder comorbidity: clinical assessment and therapeutic implications. Front Psychiatry 2011; 2: 70.
- Mancebo MC, Grant JE, Pinto A, Eisen JL, Rasmussen SA. Substance use disorders in an obsessive compulsive disorder clinical sample. J Anxiety Disord 2009; 23: 429-35.
- Kobak KA, Taylor LVH, Bystritsky A, Kohlenberg CJ, Griest JH, Tucker P et al. St John’s wort versus placebo in obsessive-compulsive disorder: results from a double-blind study. Int Clin Psychopharmacol 2005; 20: 299-304.
- Sarris J, Camfield D, Berk M. Complementary medicine, self-help, and lifestyle interventions for obsessive-compulsive disorder (OCD) and the OCD spectrum: a systematic review. J Affect Disord 2012; 138: 213-21.
- Zohar J, Westenberg HGM. Anxiety disorders: a review of tricyclic antidepressants and selective serotonin reuptake inhibitors. Acta Psychiatr Scand 2000; 403: 39-49.
- Tan KR, Brown M, Labouèbe G, Yvon C, Creton C, Fritschy J-M et al. Neural bases for addictive properties of benzodiazepines. Nature 2010; 463: 769-74.
- Hajak G, Müller WE, Wittchen HU, Pittrow D, Kirch W. Abuse and dependence potential for the non-benzodiazepine hypnotics zolpidem and zopiclone: a review of case reports and epidemiological data. Addiction 2003; 98: 1371-8.
- Jenicke MA. Obsessive-compulsive disorder: efficacy of specific treatments as assessed by controlled trials. Psychopharmacol Bull 1993; 29: 487-99.
Expert review: Dr Paul Blenkiron
Series Editor: Dr Phil Timms
Series Manager: Thomas Kennedy
Published: Oct 2019
Review due: Oct 2022
© Royal College of Psychiatrists